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Title   부인과 악성종양에 있어서 신피막하 종양이식 분석법의 판단기준으로서 PAPAN Score 의 효용성 ( Value of PAPAN Score as Parameter of Subrenal Capsule Tumor Implant Assay in Gynecological Malignant Tumors )
Publicationinfo   1991 Jan; 023(04): 728-740.
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Abstract   The purpose of this study was to document that subrenal capsule tumor implant assay (SRCA) requires a histopathologic assessment of implanted tumor and whether this assessment could be an objective parameter of chemosensitive testing. In SRCA the implanted tumor under the renal capsule showed various histopathologic changes after chemotherapy. They were regression of cancer, reduction in the number of cancer cell, tumor stroma, mitoses, and increase in tumor necrosis. These histopathologic changes were defined as PAPAN score(Preservation of cancer cells, Amount of cancer cells, Preserva- tion of tumor stroma, Amount of mitoses, Necrosis). A total of 81 SRCA were performed with gynecologic malignancies against severa1 chematherapeutic agents or their combination and the histopathologic changes of implanted tumor were analyzed. The results were as fo1lows: 1) The evaluability of SRCA was 93% and cervical carcinoma was the most sensitive to EP combination chemotherapy(85%). In ovarian cancer, CAP combination chemotherapy showed 90% chemosensitivity and endometrial cancer was 100% sensitive to 5-FU and epirubicin. 2) In cervical cancer, the PAPAN score was 4.1 following 5-FU chemotherapy of which the sensitivity was 53%, 4.5 following CTX(sensitivity' 45%) and 1.7 after EP combination therapy (sensitivity: 85%). 3) In ovarian cancer, the PAPAN score was 4.4 after CTX(sensitivity: 40%L 2.8 following adriamycin(sensitivity. 60%) and 0.9 following CAP combination chemotherapy(sensitivity: l00%) In endometrial carcinoma, the PAPAN score was 4.2 following cisplatin(sensitivity: 0%, 2.9 after CTX.(sensitivity. 40%) and 1.2 after 5-FU chemotherapy(sensitivity. 100%). In conclusion, this preliminary study showed that the PAPAN score was inversely proportional to chemotherapeutic responsiveness in gynecologic malignancies. So the histopathologic changes(PAPAN score) can be adopted as an objective parameter of SRCA for enhancing the usefulness of the SRCA as an in vivo chemosensitivity test and saving time and effort to perform SRCA.
저 자   강순범(Soon Beom Kang),김종혁(Jong Hyeok Kim),정동근(Dong Geun Chung),조경훈(Kyeong Hoon Cho),김승철(Seung Cheol Kim),이효표(Hyo Pyo Lee)